With Dom and Letty married, Brian and Mia retired and the rest of the crew exonerated, the globe-trotting team has found some semblance of a normal life. They soon face an unexpected challenge when a mysterious woman named Cipher forces Dom to betray them all. Now, they must unite to bring home the man who made them a family and stop Cipher from unleashing chaos.
Peter Quill and his fellow Guardians are hired by a powerful alien race, the Sovereign, to protect their precious batteries from invaders. When it is discovered that Rocket has stolen the items they were sent to guard, the Sovereign dispatch their armada to search for vengeance. As the Guardians try to escape, the mystery of Peter's parentage is revealed.